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Faculty of Biochemical and Chemical engineering




Jordan, E.N., Shirali Hossein Zade, R., Pillay, S., van Lent, P., Abeel, T., and Kayser, O. Integrated omics of Saccharomyces cerevisiae CENPK2-1C reveals pleiotropic drug resistance and lipidomic adaptations to cannabidiol. npj Syst Biol Appl 2024, 10. DOI:

Schmidt, C., Aras, M., and Kayser, O.  Engineering cannabinoid production in Saccharomyces cerevisiae. Biotechnol J. 2024,

Jordan, E.N., Schmidt, C., and Kayser, O. Foldseek reveals a CBGA prenylating enzyme GlyMa_02G168000 from Glycine max. Biochem Biophys Res Com 2024. DOI:

Jordan, E.N., Nguyen, G.-N., Reynoso-Moreno, I., Gertsch, J., and Kayser, O. Synthesis of stilbenyl and bibenzyl cannabinoids and analysis of their cannabimimetic potential. Synthesis 2024, 56. DOI: 10.1055/s-0042-1751539

Spitzer, S., Wloka, J, Pietruszka, J., and Kayser, O. Generation of cannabigerolic acid derivatives and their precursors using the promiscuity of the aromatic prenyltransferase NphB. ChemBioChem 2023. DOI:10.1002/cbic.202300441.

Thomas, F. and Kayser, O. Improving CBCA synthase activity through rational protein design. J Biotechnology 2023, 363:40-49.

Nguyen, G.-N., Jordan, E.N.,  and Kayser, O. Protecting-group-free synthesis of novel cannabinoid-like 2,5-dihydrobenzoxepines. Synthesis 2022, 54, A-K. DOI:10.1055/s-0042-1751361.

Nguyen, G.-N., Jordan, E.N., and Kayser, O. Synthetic strategies for rare cannabinoids derived from Cannabis sativa. J Nat Products 2022, DOI: 10.1021/acs.jnatprod.2c00155.

Jordan, E.N., Nguyen, G.-N., Piechot, A., and Kayser, O. Cannabinoids as new drug candidates for the treatment of glaucoma. Planta Med 2022, 88: 1-18. DOI: 10.1055/a-1665-3100.

Thomas, F. and Kayser, O. Natural deep eutectic solvents enhance cannabinoid biotransformation. Biochem Engin J, DOI: 10.1016/j.bej.2022.108380

Pitakbut, T., Spiteller, M., and Kayser, O. Genome mining and gene expression reveal maytansine biosythetic genes from endophytic communities living inside Gymnosporia heterophylla (Eckl. and Zeyh.) Loes. and the relationship with the plant biosynthetic gene, Friedelin Synthase. Plants 2022, 11:321.

Riga, R., Happyana, N., Quentmeier, A., Zamarelli, C., Kayser, O. and Hakim, E.H. Secondary metabolites from Diaporthe lithocarpus islated from Artocarpus heterophyllus. Nat Prod Res. 2021, 35:2324-2328.

Pitakbut, T., Nguyen, G.-N., and Kayser, O. Activity of THC, CBD, and CBN on human ACE2 and SARS-CoV1/2 main protease to understand antiviral defense mechanism. Planta Med 2021, DOI: 10.1055/a-1581-3707.

Hussain, T., Jeena, G., Pitakbut, T., Vasilev, N., and Kayser, O. Cannabis sativa research trends, challenges and new-age perspectives. ISCIENCE 2021, 24, DOI: 10.1016/j.isci.2021.103391.

Daoud, F., Zühlke, S., Spiteller, M., and Kayser, O. Elimination of diethylenetriaminepentaacetic acid from effluents from pharmaceutical production by ozonation. Ozone: Science & Engineering, DOI: 10.1080/01919512.2021.1983409.

Hillebrands, L., Lamshoeft, M., Lagojda, A., Stork, A. and Kayser, O. In vitro metabolism of tebuconazole, flurtamone, fenhexamid, metalaxyl-M and spirodiclofen in Cannabis sativa L. (hemp) callus cultures. Pest Manag Sci 2021, DOI: 10.1002/ps.6575.

Pitakbut, T., Spiteller, M., and Kayser, O. In vitro production and exudation of 20-hydroxymaytenin from Gymnosporia heterophylla (Eckl. and Zeyh.) Loes. cell culture. Plants 2021, 10, 1493. DOI: 10.3390/plants100781493.

Thomas, F., Schmidt, C., and Kayser, O. Bioengineering studies and pathway modeling of the heterologous biosynthesis of tetrahydrocannabinolic acid in yeast. Appl Microbiol Biotechnol 2020, DOI: 10.1007/s00253-020-10798-3.

Hillebrand, L., Lamshoeft, M., Lagojda, A., Stork, A., and Kayser, O.Evaluation of callus cultures to elucidate the metabolism of tebuconazole, flurtamone, fenhexamid, and metalasyl-m in Brassica napus L, Glycine max (L.) Merr., Zea mays L., and Triticum aestivum L. J Agric Food Chem 2020, 68:14123-14134.

Nguyen, G.-N., and Kayser, O. Biosynthesis and chemical modifications of minor cannabinoids. In: eLS. John Wiley & Sons, LTD: Chichester. May 2020. DOI: 10.1002/9780470015902.a0028875.

Hensel, A., Bauer, R., Heinrich, M., Spiegler, V., Kayser, O., Hempel, G., Kraft, K. Challenges at the time of Covid-19: Opportunities and innovations in antivirals from nature. Planta Med 2020, 86: 659-664.

Daoud, F., Zuehlke, S., Spiteller, M., and Kayser, O. Ozonation of rivaroxaban production waste wter and comparison of generated transformation products with known in vivo and in vitro metabolites. Sci Total Environ 2020, 714, 136825, doi: 10.1016/j.scitotenv.2020.136825

Averesch, N.J.H. and Kayser, O.Editorial: Biotechnological Production and Conversion of Aromatic Compounds and Natural Products. Front. Bioeng. Biotechnol. DOI: 10.3389/fbioe.2020.00646

Rodziewicz, P. and Kayser, O. Cultivation and breeding of Cannabis sativa L. for medicinal use. In: Handbook of Plant Breeding - Medicinal, aromatic and stiumlant plants.Vol. 12.  Eds.: Novak, J., and Blüthner, J.-W. Springer International Publishing, Springer Nature Switzerland AG, ISBN 987-3-030-38791-4, 2020.

Schachtsiek, J, Hussain, T., Azzouhri, K., Kayser, O. and Stehle, F. Virus-induced gene silencing (VIGS) in Cannabis sativa L. Plant Methods 2019, doi: 10.1186/213007-019-0542-5.

Thomas, F., Kayser, O. Minor cannabinoids of Cannabis sativa L. J. Med Sciences 2019, 88: 141-149.

Vautz, W., Hariharan, C., and Kayser, O. Fast Detection of recent Cannabis sativa L. consumption in exhaled breath using a mobile ion mobility spectrometer. J. Forensic Res Crime Stud 2019, 3: 1-11.

Riga, R., Happyana, N., Quentmeier, A., Zammarelli, C., Kayser, O., and Hakim, E.H. Secondary metabolites from Diaporthe lithocarpus isolated from Artocarpus heterophyllus. Nat Prod Res 2019, DOI: 10.1080/14786419.2019.1672685

Heinrich, M., Appendino, G., Effert, T., Fürst, R., Izzo, A.A., Kayser, O., Pezzuto, J.M., Viljoen, A. Best practice in research - overcoming common challenges in phytopharmacological research. J. Ethnopharm 2019, DOI: 10.1016/j.jep.2019.112230.

Rodziewicz, P., Loroch, S., Marczak, L., Sickmann, A. and Kayser, O. Cannabinoid synthases and osmoprotective metabolites accumulate in the exudates of Cannabis sativa L. glandular trichomes. Plant Sci 2019, 284: 108-116.

Hussain, T., Espley, R.V., Gertsch, J., Whare, T., Stehle, F. and Kayser, O. Demystifying the liverwort Radula marginata, a critical review on its taxonomy, genetics, cannabinoid phytochemistry and pharmacology. Phytochem Reviews 2019, 18: 953-965.

Kayser, O. Trends and prospects in biotechnology. Trends and Prospects in Medical and Pharma Biotechnologies in Europe 2019, 03.06 -04.06.2019, Bratislava, Slovakia.

Kayser, O. Ethnobotany and medicinal plant biotechnology: From tradition to modern aspects of drug development. Trends and Prospects in Medical and Pharma Biotechnologies in Europe 2019, 03.06.-04.06.2019, Bratislave, Slovakia.

Kohnen-Johannsen, K.L., Kayser, O. Tropane alkaloids: chemistry, pharmacology, biosynthesis and production. Molecules 2019, 24: 796.

Aati, H., El-Gamal, A., and Kayser, O. Chemical composition and biological activity of the essential oil from the root of Jatropha pelargoniifolia Courb. native to Saudi Arabia. Saudi Pharm J 2019, 27: 88-95.

Aati, H., El-Gamal, A., Shaheen, H., and Kayser, O. Traditional use of ethnomedicinal native plants in the Kingdom of Saudi Arabia. J Ethnobiol Ethnomed 2019, 15: 1.

Ebersbach, P., Stehle, F., Kayser, O., and Freier, E. Chemical fingerprinting of single glandular trichomes of Cannabis sativa by coherent anti-Stokes Raman scattering (CARS) microscopy. BMC Plant Biol 2018, 18: 275.

Zirpel, B., Kayser, O., and Stehle, F. Elucidation of structure-function relationship of THCA and CBDA synthase from Cannabis sativa L. J Biotechnol 2018, 284: 17-26.

Bergen, I., Liedtke, S., Güssgen, S., Kayser, O., Hariharan, C., Drees, C., and Vautz, W. Calibration of complex mixtures in one sweep. Int J Ion Mobility Spectrometry 2018: DOI 10.121: 55-64.

Hussain, T., Plunkett, B., Ejaz, M., Espley, R. V., and Kayser, O. Identification of putative precursor genes for the biosynthesis of canabinoid-like compound in Radula marginata. Frontiers in Plant Science 2018, 9: 1-17.

Aati, H.Y., El-Gamal, A.A., Kayser, O., and Ahmed, A.F. The phytochemical and biological investigation of Jatropha pelargoniifolia root native to the Kingdom of Saudi Arabia. Molecules 2018, 23: 8.

Kayser, O. Ethnobotany and medicinal plant biotechnology: From tradition to modern aspects of drug development. Planta Med 201,: 84,:834-838.

Geissler, M., Volk, J., Stehle, F., Kayser, O., and Warzecha, H. Subcellular localization defines modification and production of Delta9-tetrahydrocannabinolic acid synthase in transiently transformed Nicotiana benthamiana. Biotechnol Lett 2018, 40: 981-987.

Schachtsiek, J., Warzecha, H., Kayser, O., and Stehle, F. Current perspectives on biotechnological cannabinoid production in plants.Planta Media 2018, 84: 214-220.

Zirpel, B., Degenhardt, F., Zammarelli, C., Wibberg, D., Kalinowski, J., Stehle, F., and Kayser. O. Optimization of Delta9-tetrahydrocannabinolic acid synthase production in Komagataella phaffii via post-translational bottleneck identification. J Biotechnol 2018, 272-273: 40-47.   

Kohnen, K.L., Sezgin, S., Spiteller, M., Hagels, H., and Kayser, O. Localization and organization of scopolamine biosynthesis in Duboisia myoporoides R. Br. Plant Cell Physiol. 2017, doi: 10.1093/pcp/pcx165.

Kayser, O. Natural product biotechnology - limits and expectations. Webinar.

Zirpel, B., Degenhardt, F., Martin, C., Kayser, O. and Stehle, F. Engineering yeasts as platform organisms for cannabinoid biosynthesis. J Biotechnol;

Angela, C., Hansen, E.H., Kayser, O., Carlsen, S., and Stehle, F. Designing microorganisms for heterologous biosynthesis of cannabinoids. FEMS Yeast Res 2017 fox037.doi: 10.1093/femsyr/fox037.

Ullrich, S. U., Rothauer, A., Hagels, H., and Kayser, O. Influence of light, temperature, and macronutrients on growth and scopolamine biosynthesis in Duboisia species. Planta Med 2017, DOI 10.1055/s-0043-106435.

Fararg, S., and Kayser, O. The Cannabis Plant: Botanical Aspects. In: Handbook of Cannabis and Related Pathologies - Biology, Pharmacology, Diagnosis, and Treatment. Academic Press. ISBN: 9786128007563. 2017. 3-12.

Degenhardt, F., Stehle, F., and Kayser, O. The Biosynthesis of Cannabinoids. In: Handbook of Cannabis and Related Pathologies - Biology, Pharmacology, Diagnosis, and Treatment. Academic Press. ISBN. 9786128007563. 2017. 13-23.

Ullrich, S.F., Hagels, H., and Kayser, O. Scopolamine: a journey from the field to clinics. Phytochem Rev 2016, DOI: 10.1007/211101-016-9477-x

Sasse, J., Schlegel, M., Borghi, L., Ullrich, F., Lee, M., Liu, G.-W., Giner, J.-L., Kayser, O., Bigler, L., Martinoia, E., and Kretzschmar, T. Petunia hybrida PDR2 is involved in herbivore defense by controlling steroidal contents in trichomes. Plant, Cell & Environment 2016, DOI: 10.1111/pce. 12828.

Ullrich, S.F., Averesch, N.J.H., Castellanos, L., Choi, Y.H., Rothauer, A. and Kayser, O. Discrimination of wild types and hybrids of Duboisia myoporoides and Duboisia leichhardtii at different growth stages using 1H NMR-based metabolite profiling and tropane alkaloids-targeted HPLC-MS analysis. Phytochemistry 2016, 131: 44-56.

Hariharan, C., Kayser, O. Innovative and rapid detection of marihuana consumption from direct breath analysis. PITTCON 2016, Atlanta, Georgia, USA, March 6-10.

Happyana, N., Kayser, O. Monitoring metabolite profiles of Cannabis sativa L. trichomes during flowering period using 1H NMR-based metabolomics and Real-Time PCR. Planta Med 2016, DOI: 10.1055/s-0042-108058.

Wang, W.-X., Kusari, S., Laatsch, H., Golz, C., Kusari, P., Strohmann, C., Kayser, O.,  Spiteller, M.. Antibacterial azaphilones from an endophytic fungus, Colletotrichum sp. BS4. J Nat Prod 2016, 79: 704-710.


Gruchattka, E., Kayser, O. In vivo validation of in silico predicted metabolic engineering strategies in yeast: disruption of alpha-ketoglutarate dehydrogenase and expression of ATP-citrate lyase for terpenoid production. PLoS One. 2015, 10(12): e0144981.

Farag, S., Kayser, O. Cultivation and breeding of Cannabis sativa L. for preparation of standardized extracts for medicinal purposes. In: Medicinal and aromatic plants of the world. Vol. 1, Springer Netherlands, Dordrecht, ISBN 978-94-017-9810-5, 2015, 165-186.

Farag, S., Kayser, O. Cannabinoids production by hairy root cultures of Cannabis sativa L.. Am. J. Plant Sciences 2015, 6: 1874-1884.

Li, G., Kusari, S., Kusari, P., Kayser, O., Spiteller, M. Endophytic Diaporthe sp. LG23 produces a potent antibacterial tetracyclic triterpenoid. J. Nat. Prod. 2015, 78: 2128-2132

Zirpel, B., Stehle, F., Kayser, O. Production of Delta9-tetrahydrocannabinolic acid from cannabigerolic acid by whole cells of Pichia (Komagataella) pastoris expressing Delta9-tetrahydrocannabinolic acid synthase from Cannabis sativa l. Biotechn. Lett. 2015. doi: 10.1007/s10529-015-1853-x.

Kusari, P. Kusari, S., Spiteller, M., Kayser, O. Implications of endophyte-plant crosstalk in light of quorum responses for plant biotechnology. Appl. Microbiol. Biotechnol. 2015, 99: 5383-5390.

Wang, W.-X., Kusari, S., Sezgin, Lamshöft, M., Kusari, P., Kayser, O., Spiteller, M. Hexacyclopeptides secreted by an endophytic fungus Fusarium solani N06 act as crosstalk molecules in Narcissus tazetta. Appl. Microbiol. Biotechnol. 2015, 99: 7651-7662.

Kusari, S., Lamshöft, M., Kusari, P., Gottfried, S., Zühlke, S., Louven, K., Hentschel, U., Kayser, O., Spiteller, M. Endophytes are hidden producers of maytansine in Putterlickia roots. J. Nat. Prod. 2014, 77: 2577-2584 (selected as ACS editor's choice article).

Kusari, P., Kusari, S., Spiteller, M., Kayser, O. Biocontrol potential of endophytes harbored in Radula marginata (liverwort) from the New Zealand ecosystem. Antonie van Leeuwenhoek 2014, 106: 771-788.

Kusari, P., Kusari, S., Lamshöft, M., Sezgin, S., Spiteller, M. Kayser, O. Quorum quenching is an antivirulence strategy employed by endophytic bacteria. Appl Microbiol Biotechnol May 2014, 98: 7173-7183.

Elfahmi, Woerdenbag, Herman J., Kayser, O. Jamu: Indonesian traditional herbal medicine towards rational phytopharmacological use. J. Herbal Med. 2014, 4: 51-73.

Kusari, P., Spiteller, M., Kayser, O., Kusari, S. Recent advances in research on Cannabis sativa L. endophytes and their prospect for the pharmaceutical industry. In: Kharwar, R.N. et al. (eds.) Microbial Diversity and Biotechnology in Food Security, Springer India, 2014, Book Part I, 3-15. ISBN: 978-81-322-1800-5

Staniak, A., Bouwmeester, H., Fraser, P.D., Kayser, O., Martens, S., Tissier, A., van der Krol, S., Wessjohann, L., Warzecha, H. Natural products - learning chemistry from plants. Biotechnol J. 2014, 9(3): 326-336.

Staniak, A., Bouwmeester, H., Fraser, P.D., Kayser O., Martens, S., Tissier, A., van der Krol, S., Wessjohann, L. & Warzecha, H. Natural products - modifying pathways in plants. Biotechnol J. 2013. 8: 1159-1171.

Gruchattka, E., Hädicke, O., Klamt, S., Schütz, V. & Kayser, O. In silico profiling of Escherichia coli and Saccharomyces cerevisiae as terpenoid factories. Microb Cell Fact., 2013. 12: 84

Kusari, P., Kusari, S., Spiteller, M. & Kayser, O. Endophytic fungi harbored in Cannabis sativa L.: Diversity and potential as biocontrol agents against host plant-specific phytopathogens. Fungal Diversity. 2013. 60: 137-151. (Special issue dedicated to COST Action FA1103: Endophytes in Biotechnology and Agriculture).

Mellilo, E., Stroikromo, R., Quax, W.J. & Kayser, O. Production of alpha-cuprenene in Xanthophyllomyces dendrorhous: a step closer to a potent terpene biofactory. Microb Cell Fact., 2013. 12:13

Happyana, N., Agnolet, S., Muntendam, R., Van Dam, A., Schneider, B. & Kayser, O. Analysis of cannabinoids in laser-microdissected trichomes of medicinal Cannabis sativa using LCMS and cryogenic NMR. Phytochemistry. 2013. 87: 51-59.

Hendrawati, O., Hille, J., Woerdenberg, H.J., Quax, W.J. & Kayser, O. In vitro regeneration of wild chervil (Anthriscus sylvestris L.). In Vitro Cell Dev Biol Plant. 2012. 48(3):355-361.

 Limsuwan, S., Kayser, O. & Voravuthikunchai, S.P. Antibacterial activity of Rhodomyrtus tomentosa (Aiton) Hassk. leaf extract against clinical isolates of Streptococcus pyogenes. Evid Based Complement Alternat Med. 2012. 2012: 697183.

Melillo, E., Muntendam, R., Quax, W.J. & Kayser, O. Heterologous expression of pentalenene synthase (PSS) from Streptomyces UC5319 in Xanthophyllomyces dendrorhous. J Biotechnol. 2012. 161(3): 302-307.

Muntendam, R., Happyana, N., Erkelens, T., Bruining, F. & Kayser, O. Time dependent metabolomics and transcriptional analysis of cannabinoid biosynthesis in Cannabis sativa var. Bedrobionol and Bediol grown under standardized condition and with genetic homogeneity.


Limsuwan, S., Hesseling-Meinders, A., Voravuthikunchai, S.P., van Dijl, J.M. & Kayser, O. Potential antibiotic and anti-infective effects of rhodomyrtone from Rhodomyrtus tomentosa (Aiton) Hassk. on Streptococcus pyogenes as revealed by proteomics. Phytomedicine. 2011. 18(11):934-940.

Hendrawati, O., Woerdenberg H.J., Hille J. & Kayser, O. Seasonal variations in the deoxypodophyllotoxin content and yield of Anthriscus sylvestris L. (Hoffm.) grown in the field and under controlled conditions. J Agric Food Chem. 2011. 59(15):8132-8139.

Hendrawati, O., Woerdenberg, H.J., Michiels, P.J., Aantjes, H.G., van Dam A. & Kayser, O. Identification of lignans and related compounds in Anthriscus sylvestris by LC-ESI-MS/MS and LC-SPE-NMR. 2011. 72(17):2172-2179.

Kayser, O., Ryden, A., Bouwmeester, H., Ruyter Spira, C., Osada, H., Muranaka, T. The molecular cloning of dihydroartemisinic aldehyde reductase and its implication in artemisinin biosynthesis in Artemisia annua. Planta Med. 2011. 77: Sl28.

Rydén, A.M., Ruyter-Spira, C., Quax, W.J., Osada, H., Muranaka, T., Kayser, O., & Bouwmeester, H. The molecular cloning of dihydroartemisinic aldehyde reductase and its implication in artemisinin biosynthesis in Artemisia annua. Planta Med. 2010. 76(15):1778-1783.

Rydén, A.M., Ruyter-Spira, C., Litjens, R., Takahashi, S., Quax, W., Osada, H., Bouwmeester, H., & Kayser,O. Molecular cloning and characterization of a broad substrate terpenoid oxidoreductase from Artemisia annua. Plant Cell Physiol. 2010. 51(7):1219-1228.

Staniek, A., Muntendam, R., Woerdenbag, H.J., & Kayser, O. Essential oil constituents derived from different organs of a relictual conifer Wollemia nobilis. Biochemical Systematics and Ecology. 2010. 38(2):131-135.

Lemke, A., Petri, B, Kiderlen, A.F., & Kayser, O. Delivery of amphotericin B nanosuspensions to the brain and determination of activity against Balamuthia mandrillaris amebae. Nanomedicine. 2010. 6(4):597-603.

Insanu, M., Anggadireja, J., Kayser, O. Isolation of curcacycline A from latex of Jatropha curcas and its antibiotic and cytotoxic effect. Planta Med. 2010. 76: P435.


Rydén, A.M. Identification, Characterisation and Expression of Early Genes from Artemisia annua.

Staniek, A. Endophytes as alternative paclitaxel sources: chemistry and genetics of Taxomyces andreanae and the endophytic flora of Wollemia nobilis.

Limsuwan, S., Trip, E.N., Kouwen, T.R., Piersma, S., Hiranrat, A., Mahabusarakam, W., Voravuthikunchai, S.P., van Dijl, J.M., & Kayser, O. Rhodomyrtone: a new candidate as natural antibacterial drug from Rhodomyrtus tomentosa. Phytomedicine 2009. 16(6-7):645-51.

Muntendam, R., Melillo, E., Ryden, A., & Kayser, O. Perspectives and limits of engineering the isoprenoid metabolism in heterologous hosts. Appl Microbiol Biotechnol. 2009. 84(6):1003-1019.

Staniek, A., Woerdenbag, H.J., & Kayser, O. Taxomyces andreanae: A Presumed Paclitaxel Producer Demystified? Planta Med. 2009. 75(15):1561-1566.

Azizi, M., Davareenejad, G., Bos, R., Woerdenbag ,H.J., & Kayser, O.

Essential oil content and constituents of black zira (Bunium persicum [Boiss.] B. Fedtsch.) from Iran during field cultivation (domestication).

Journal of Essential Oil Research. 2009. 21:78-82.

Aslan, S., Kartal, M., Kurucu, S., Kuiper, J.M., Kruizinga, W.H., Bos, R., Woerdenbag, H.J., & Kayser, O. Composition of the essential oil from roots and rhizomes of Valeriana phu L. growing wild in Turkey. Journal of Essential Oil Research. 2009. 21:437-440.

Özbay, Ö., Aslan, S., Kartal, M., Kurucu, S., Bos, R., Woerdenbag, H.J., & Kayser, O. Preliminary examination of the composition of the essential oil from roots and rhizomes of Valeriana alpestris Stev. growing in Turkey. Journal of Essential Oil Research. 2009. 21:555-557.

Flemming, T., Kayser, O. Heterologous expressed human cytochromes are useful tools in synthesis of thymoquinone. Planta Med. 2009. 75: PE41.

Duarte, N., Kayser, O., Abreu, P., & Ferreira M.J. Antileishmanial activity of piceatannol isolated from Euphorbia lagascae seeds. Phytoter Res. 2008. 22(4):455-457.

Julsing, M.K., Vasilev, N.P., Schneidman-Duhovny, D., Muntendam, R., Woerdenbag, H.J., Quax, W.J., Wolfson, H.J., Ionkova, I., & Kayser, O. Metabolic stereoselectivity of cytochrome P450 3A4 towards deoxypodophyllotoxin: In silico predictions and experimental validation. Eur. J. Med. Chem. 2008. 43(6):1171-1179.

Staniek, A., Woerdenbag, H.J.,Kayser, O. Endophytes: exploiting biodiversity for the improvement of natural product - based drug discovery. Journal of Plant Interactions. 2008. 3(2):75-93.

Seifert, K., Lemke, A., Croft, S. L., & Kayser, O. Antileishmanial structure-activity relationships of synthetic phospholipids: In vitro and in vivo activities of selected derivatives. Antimicrobial Agents and Chemotherapy. 2007. 51(12):4525-4528.



Lemke, A. New formulation approaches for the leishmanicidal drug Miltefosine and for the polyene antibiotic Amphotericin B. February 15, 2008. ISBN printed version: 978-90-367-3273-4

Julsing, M.K., Rijpkema, M., Woerdenbag, H.J., Quax, W.J., & Kayser, O. Functional analysis of genes involved in the biosynthesis of isoprene in Bacillus subtilis. Appl Microbiol Biotechnol. 2007. 75(6):1377-1384.

Bos, R., Windono, T., Woerdenbag, H.J.,Boersma,Y.L., Koulman, A., Kayser,O. HPLC-photodiode array detection analysis of curcuminoids in Curcuma species indigenous to Indonesia. Phytochem. Anal. 2007 Mar;18(2):118-22.

Bos,R.; Woerdenbag,H.J.; Kayser,O.; Quax,W.J.; Ruslan,K.; Elfahmi. Essential oil constituents of Piper cubeba L. fils. from Indonesia. Journal of Essential Oil Research 19 (1): 14-17

Seifert,K.; Lemke,A.; Croft,S.L.; Kayser,O. Anti-leishmanial structure-activity-relationships of synthetic phospholipids: in vitro and in vivo activity of selected derivatives. Antimicrob. Agents Chemother 2007 Dec;51(12):4525-4528.

Elfahmi, Ruslan, K., Batterman, S., Bos, R., Kayser, O., Woerdenbag, H.J., Quax, W.J. Lignan profile of Piper cubeba, an Indonesian medicinal plant. Biochemical Systematics and Ecology 35 (2007) 397-402.

Staniek, A., Woerdenbag, H.J., Czepnik, M., Szamlek, M., Baer-Dubowska, W., Krawczyk, K., Budzianowski, J., Zwart, J.W., Kayser, O. Endophytic paclitaxel synthesizers - search and investigation. Planta Med. 2007. 73: P_641.

Koulman, A., Hendrawati, O., Batterman, S., Van Putten, F.M.S., Bos, R., Kayser, O. The seasonal variations of lignan profiles in Antrhiscus sylvestris (L.) Hoffm. Planta Med. 2007. 73: P_112.


Chapters in books:

A.-M. Rydén, O. Kayser. Chapter: Chemistry, Biosynthesis and Biological Activity of Artemisinin and Related Natural Peroxides. In Book Series: Topics in Heterocyclic Chemistry,Volume 9/2007, p 1-31. Book: Bioactive Heterocycles III. Khan, M.T.H. (Ed.), Publisher Springer Berlin / Heidelberg ISSN 1861-9282 (Print), 1861-9290 (Online), ISBN 978-3-540-73401-7

T. Flemming, R. Muntendam, C. Steup, O. Kayser. Chapter: Chemistry and Biological Activiy of Tetrahydrocannabinol and its Derivatives. In Book Series: Topics in Heterocyclic Chemistry, Volume 10/2007, p 1-42. Book: Bioactive Heterocycles IV. Khan, M.T.H. (Ed.), Springer-Verlag Berlin / Heidelberg ISSN 1861-9282, ISBN 978-3-540-73403-1


Magazine articles:

Julsing MK, Woerdenbag HJ, Kayser O. Combinatoriële biosynthese. Plantenstoffen staan weer volop in de belangstelling. Conceptuur 2007; no. 51: 6-7.

Elfahmi, Batterman, S., Koulman, A., Hackl, T., Bos, R., Kayser, O., Woerdenbag, H. J., & Quax, W. J. Lignans from cell suspension cultures of Phyllanthus niruri, an Indonesian medicinal plant. J. Nat. Prod. 2006. 69:55-58.

Vasilev, N.P., Julsing, M.K., Koulman, A., Clarkson, C., Woerdenbag, H.J., Ionkova, I., Bos, R., Jaroszewski, J.W., Kayser, O., & Quax, W.J. Bioconversion of deoxypodophyllotoxin into epipodophyllotoxin in E. coli using human cytochrome P450 3A4. J Biotechnol. 2006. 126(3):383-393.

Lemke, A., Kayser, O. HPLC detection of miltefosine using an evaporative light scattering detector. Pharmazie. 2006. 61(5):406-408.

Vasilev,N., Elfahmi, Bos, R., Kayser, O., Momekov, G., Konstantinov, S., & Ionkova, I. Production of justicidin B, a cytotoxic arylnaphthalene lignan from genetically transformed root cultures of Linum leonii. J. Nat. Prod. 2006. 69:1014-1017.

Kaneshiro, E.S. , Basselin, M. , Merali, S., & Kayser, O. Ubiquinone Synthesis and its Regulation in Pneumocystis carinii.  J. Eukaryot. Microbiol. 2006. 53(6):435-44.



Elfahmi. Phytochemical and Biosynthetic Studies of Lignans. With a Focus on Indonesian Medicinal Plants. June 26, 2006. ISBN 90-902-0771-6

Julsing, M.K. Bioconversion and combinatorial biosynthesis of selected terpenoids and lignans. October 13, 2006. ISBN printed version: 90-367-2762-6. ISBN electronical version: 90-367-2763-4.



Kayser, O, Quax, W (2006). Medicinal Plant Biotechnology. 2 vols. From Basic Research to Industrial Applications.

Wiley-VCH, Heidelberg (ISBN: 3527314431 )

Kayser, O. (2006). Podstawy Biotechnologii Farmaceuttycznej. B.G. Teubner Verlag, GWV Verlagsgesellschaft, Wiesbaden

Lemke,A., Kiderlen,A., & Kayser,O. Amphotericin B. Applied Microbiology and Biotechnology. 2005. 68:151-162.

Maskey,R.P., Helmke,E., Kayser,O., Fiebig,H.H., Maier,A., Busche,A., & Laatsch,H. Anti-cancer and antibacterial trioxacarcins with high anti-malaria activity from - a marine Streptomycete and their absolute stereochemistry. Journal of Antibiotics. 2004. 57:771-779.

Kayser,O., Lemke,A., & Hernandez-Trejo,N. The impact of nanobiotechnology on the development of new drug delivery systems. Current Pharmaceutical Biotechnology. 2005. 6(1):3-5.

Kolodziej, H., Kayser, O., Kiderlen, A.F., Ito, H., Hatano, T., Yoshida, T., Foo, L.Y. Antileishmanial activity of hydrolyzable tannins and their mudulatory effects on nitric oxide and tumour necrosis factor-alpha release in macrophages in vitro. Planta Med. 2001. 67: 825-832.

Kayser, O., Kiderlen, A.F., Brun, R. In vitro activity of aurones against Plasmodium falsipharum strains K1 and NF54. Planta Med. 2001. 67: 718-721.

Kayser, O., Waters, W.R., Woods, K.M., Upton, S.J., Keithly, J.S., Kiderlen, A.F. Evaluation of in vitro activity of aurones and related compounds against Cryptosporidium parvum. Planta Med. 2001. 67: 722-725.

Kayser, O., Kiderlen, A.F., Folkens, U., Kolodziej, H. In vitro leishmanicidal activity of aurones. Planta Med. 1998. 65: 316-319.