Location & approach

By car

The campus of the Technical University of Dortmund is located near the Dortmund West interchange, where the A45 Sauerland line crosses the B1/A40 Ruhr expressway. The Dortmund-Dorstfeld exit on the A40 leads to Campus-Nord. The university is signposted at both exits.

By bus and train

The "Dortmund Universität" S-Bahn station is located directly on the North Campus. From here, the S-Bahn line S1 runs every 15 or 30 minutes to Dortmund main station and in the opposite direction to Düsseldorf main station via Bochum, Essen and Duisburg. In addition, the university can be reached by bus lines 445, 447 and 462. Timetable information can be found on the homepage of the Rhine-Ruhr Transport Association. DSW21 also offer an interactive route network map.

H-Bahn

One of the landmarks of the TU Dortmund is the H-Bahn. Line 1 runs every 10 minutes between Dortmund Eichlinghofen and the Technology Center via Campus South and Dortmund University S, while Line 2 commutes every 5 minutes between Campus North and Campus South. It covers this distance in two minutes.

By plane

From Dortmund Airport, the AirportExpress takes just over 20 minutes to Dortmund's main train station, and from there, the S-Bahn takes you to the university. A wider range of international flight connections is offered by Düsseldorf Airport, about 60 kilometers away, which can be reached directly by S-Bahn from the university's train station.

Plan of site & interactive map

The facilities of TU Dortmund University are located on two campuses, the larger North Campus and the smaller South Campus. In addition, some university facilities are located in the adjacent Dortmund Technology Park as well as in the city center and the wider urban area.

> Go to interactive map

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Location & approach

By car

The campus of the Technical University of Dortmund is located near the Dortmund West interchange, where the A45 Sauerland line crosses the B1/A40 Ruhr expressway. The Dortmund-Dorstfeld exit on the A40 leads to Campus-Nord. The university is signposted at both exits.

By bus and train

The "Dortmund Universität" S-Bahn station is located directly on the North Campus. From here, the S-Bahn line S1 runs every 15 or 30 minutes to Dortmund main station and in the opposite direction to Düsseldorf main station via Bochum, Essen and Duisburg. In addition, the university can be reached by bus lines 445, 447 and 462. Timetable information can be found on the homepage of the Rhine-Ruhr Transport Association. DSW21 also offer an interactive route network map.

H-Bahn

One of the landmarks of the TU Dortmund is the H-Bahn. Line 1 runs every 10 minutes between Dortmund Eichlinghofen and the Technology Center via Campus South and Dortmund University S, while Line 2 commutes every 5 minutes between Campus North and Campus South. It covers this distance in two minutes.

By plane

From Dortmund Airport, the AirportExpress takes just over 20 minutes to Dortmund's main train station, and from there, the S-Bahn takes you to the university. A wider range of international flight connections is offered by Düsseldorf Airport, about 60 kilometers away, which can be reached directly by S-Bahn from the university's train station.

Plan of site & interactive map

The facilities of TU Dortmund University are located on two campuses, the larger North Campus and the smaller South Campus. In addition, some university facilities are located in the adjacent Dortmund Technology Park as well as in the city center and the wider urban area.

> Go to interactive map

ServicePortal UniMail

New scientific article published

07/07/2025

Sketch of a yeast cell showing an overview of metabolic engineering strategies for OA biosynthesis

Kilan J. Schäfer from the Johann Goethe University Frankfurt and his co-authors have published the article "Biochemical and Metabolic Engineering of Saccharomyces cerevisiae for the Biosynthesis of Olivetolic Acid, a Key Cannabinoid Precursor" in Biotechnology Journal.

Cannabinoids comprise a large class of bioactive compounds found primarily in the plant species Cannabis sativa and are of interest due to their pharmacological and therapeutic potential. The aromatic polyketide, olivetolic acid (OA), is a major precursor in the cannabinoid biosynthesis pathway and is derived from hexanoyl-CoA and malonyl-CoA by the action of olivetol synthase (OLS) and olivetolic acid cyclase (OAC). To date, most microbial cannabinoid production systems rely on the external supplementation of hexanoic acid together with the overexpression of acyl-activating enzyme 1 from C. sativa(CsAAE1) to provide hexanoyl-CoA. Here, we implement a heterologous OA biosynthesis pathway into the yeast Saccharomyces cerevisiae and describe various biochemical and metabolic engineering strategies to overcome the need for external hexanoic acid supplementation. We ensured a sufficient endogenous supply of hexanoyl-CoA and further optimized OA production by enhancing precursor supply. Furthermore, we present a mutant phenylacetate-CoA ligase derived from Penicillium chrysogenum(PcPCL-K) which displayed superior hexanoyl-CoA ligase activity to CsAAE1. Together, these strategies enabled the production of 180 mg/L OA using shake flask cultures. Our results provide details of key metabolic engineering steps required for the biosynthetic production of cannabinoids and their precursors in S. cerevisiae.