Theses
PhD Theses
| Titel | Name | Datum |
| Diversity and beneficial mechanisms of endophytic maytansine in Gymnosporia heterophylla defense and studies on biological activities of 20-hydroxymaytenine and related natural products | Dr. Thanet Pitakbut | October 2022 |
| Evaluation of plant callus cultures to elucidate the metabolic degradation of pesticides in plants | Dr. Leonie Hillebrands | January 2022 |
| Establishment and development of methods for genetic modifications in plants and their effect on the metabolism | Dr. Julia Schachtsiek | October 2019 |
| Transcriptomic analysis of Radula marginata Taylor for identification of key genes in the biosynthesis of cannabinoid-like compounds | Dr. Tajammul Hussain | June 2019 |
| Molecular biological elucidation of late tropane alkaloid biosynthesis | Dr. Kathrin Laura Kohnen-Johannsen | June 2019 |
| Phytochemical and biological investigation of Jatropha pelargoniifolia roots native to the Kingdom of Saudi Arabia | Dr. Hanan Y. Aati | December 2018 |
| Evaluation of c-prenylating enzymes for the heterologous biosynthesis of cannabigerolic acid | Dr. Sara Friederike Degenhardt | October 2018 |
| Recombinant expression and functional characterization of cannabinoid producing enzmes in Komagataella phaffii | Dr. Bastian Zirpel | May 2018 |
| Identification, isolation and functional characterization of prenyltransferases in Cannabis sativa L. | Dr. Kathleen Pamplanyil | March 2017 |
| Influence of abiotic factors on growth and biosynthesis of secondary plant components in Duboisia species | Dr. Sophie Friederike Ullrich | December 2016 |
| Towards a platform organism for terpenoid production - in silico analysis of metabolic networks of potential hosts and in vivo validation | Dr. Evamaria Gruchattka | May 2016 |
| Metabolomics, proteomics, and transcriptomics of Cannabis sativa L. trichomes | Dr. Nizar Happyana | December 2014 |
| Isolation, identification and characterization of endophytes from Cannabis sativa L. and Radula marginata | Dr. Parijat Kusari | December 2014 |
| Cannabinoid production in Cannabis sativa L.: An in vitro approach | Dr. Sayed Farag | November 2014 |
| Xanthophyllomyces dendrorhous as a platform organism for the production of terpenes | Dr. Elena Melillo | March 2013 |
| Endophytes as alternative paclitaxel sources: chemistry and genetics of Taxomyces andreanae and the endophytic flora of Wollenia mobilis | Dr. Agata Staniak | 2010 |
| Identification, characterization and expression of early biosynthesis genes from Artemisia annua for the heterologous biosynthesis of dihydroartemisinic acid as a first step towards artemisinin production | Dr. Anna-Margareta Rydén | 2010 |
| Studies of Antrhiscus sylvestris L. (Hoffm.) - Metabolic engineering of combinatorial biosynthesis of podophyllotoxin | Dr. Oktavia Hendrawati | 2008 |
| New formulation approaches for the leishmanicidal drug Miltefosine and for the polyene antibiotic Amphotericin B | Dr. Andreas Lemke | 2008 |
Diploma and Master theses
Diploma Thesis
| Titel Expression of Hyoscyamine-6ß-Hydroxylase in genetically modified E. coli and S. cerevisiae for the conversion of Hyoscyamine to Scopolamine | Name Nils Averesch | Date December 2011 |
Master Theses
| Titel | Name | Date |
| Exploration of alternate catalysts for drug development towards anti-cancer activity | Daniel Oliver Klin | July 2022 |
| Investigation of the hydrolytic activity of glucosidases from Saccharomyces cerevisiae towards cannabinoid glycosides | Astrid Imann | June 2022 |
| Mevalonate pathway optimization to enhance GPP production by metabolic engineering in Saccharomyces cerevisiae | Janina K. Dahmen | December 2020 |
| Establishment of a testing system for quantification of geranyl pyrophosphate in metabolic engineered Saccharomyces cerevisiae | Aileen Schmidt | January 2020 |
| Establishment of an HPLC-based method for the quantitative determination of eleven different cannabinoids as well as their isolation and purification | Benjamin Ryabenky | November 2019 |
| In silico design of NphB variants to optimize the cannabigerolic acid production and characterization of promising variants in Saccharomyces cerevisiae | Saskia Spitzer | August 2019 |
| Alternative acyl-CoA synthetases for increased olivetol supply for cannabinoid synthesis in Saccharomyces cerevisiae | Lukas Greiwe | June 2019 |
| Establishment of a BioLector-based medium-throughput screening system for the evaluation of GFP-tagged protein variants in yeast | Magdalena Thoma | June 2019 |
| Optimization of Delta9-tetrahydrocannabinolic acid synthase activity in Saccharomyces cerevisiae | Christina Schmidt | December 2018 |
| Cannabis regeneration out of callus cultures | Ines de Ribeiro e Barreto Ferreira | November 2018 |
| Medium-throughput micro cultivation in yeast and crystallization of the prenyltransferase NphB | Tim-Marius Wunderlich | September 2018 |
| Detection of human volatile metabolites with stationary and optimized non-stationary gas chromatography-ion mobility spectrometers | Igor Bergen | April 2018 |
| Construction of different plasmids for the integration of olivetolic acid cyclase and olivetolic synthase into the yeast genome via DI-CRISPR/Cas9 | Jonas Heyden | January 2018 |
| Implementation of a medium-chain fatty acid detection method for the optimization of cultivation conditions to improve the hexanoic acid biosynthesis in Saccharomyces cerevisiae | Hannah Wies | January 2018 |
| Design of an automated low throughput screening platform for the optimization of Delta9-tetrahydrocannabinolic acid production in Komagataella phaffii | Florian Worm | December 2017 |
| Development of a cultivation and downstream process for high yield production of NphB for protein crystallization | Dirk Münker | December 2017 |
| Detection of Cannabis sativa and other illicit drug compounds with stationary and non-stationary gas chromatography-ion mobility spectrometers | Christoph Stoll | November 2017 |
| Design and characterization of NphB variants for an optimized cannbigerolic acid production | Martin Lukas Kares | July 2017 |
| CRISPR-Cas9 mediated pathway design for an improved precursor supply for heterologous cannabinoid production in Saccharomyces cerevisiae | Hanna Schnittger | June 2017 |
| Studies on the uptake of olivetol and olivetolic acid by Saccharomyces cerevisiae | Juliana Estrela | December 2016 |
| CRISPR-Cas9 mediated genome-editing of Saccharomyces cerevisiae | Nico Biermann | August 2016 |
| Optimization and scale up of the heterologous expression of NphB in Escherichia coli | Daniel Stalinski | August 2016 |
| Heterologous expression and functional characterization of olivetolic acid cyclase and olivetol synthase for olivetolic acid production | Tobias Gräf | August 2016 |
| Protein engineering of a soluble prenyltransferase: Design and characterization of NphB towards altered substrate specifity | Marlon Wach | July 2015 |
| Expression and purification of recombinant ß-1,3-glucanase | Christian Staubach | June 2015 |
| Optimization of recombinant human cytochrome expression in E. coli for in vitro conversion of THC metabolites | Katrin Stych | March 2015 |
| Mitochondrial targeting of heterologously expressed THCAS in Saccharomyces cerevisiae | Soeren Alsleben | March 2015 |
| Study of the composition of the essential oil and trichome fluid of Cannabis sativa and proteomic profiling of cannabinoid biosynthesis in the trichomes | Andrzej Nowicki | 2014 |
| Metabolic engineering of Saccharomyces cerevisiae for patchoulol production | Nicole Jurisch | November 2014 |
| Heterologous expression of NphB in Escherichia coli | Christine Finger | July 2014 |
| Metabolic engineering of Saccharomyces cerevisiae for monoterpenoid production | Katharina Smolczyk | July 2013 |
| Synthetic biology for the production of tetrahydrocannabinolic acid (THCA) from Cannabis sativa in Saccharomyces cerevisiae | Sara Friederike Degenhardt | May 2013 |
| Patchoulol production in Saccharomyces cerevisiae - Metabolic Engineering and process optimization | Michael Felten | October 2012 |
| Expression of Delta1-Tetrahydrocannabinolic acid synthase in Saccharomyces cerevisiae | Joanna Hajduk | September 2012 |
| Characterization of aromatic prenyltransferases from higher plants and microbial origins | Katja Straub | November 2011 |
| Production of monoterpenoids in the heterologous host Saccharomyces cerevisiae | Jacqueline Wolf | November 2011 |
| Search for cannabinoids-producing microbes among the endophytes of Cannabis sativa | Dominika Neumann | June 2011 |
| Production of scopolamine by Saccharomyces cerevisiae | Elzbieta Budziak | June 2011 |
| The use of site-directed mutagenesis in probing the acitve site of amorpha-4,11-diene synthase | Marta Ilecke | 2010 |
| Fungal endophytes and their natural products | Krysztof Przybylowski | 2008 |
| Bioanalytical characterisation of wound healing constituents from Lucilia sericata maggots | Karol Gustav Czaja | 2008 |
| Taxomyces andreanae, enigmatic producer of taxol, demystified. Detection of taxandes in the endophytes of yew | Katarzyna Krawczyk | 2007 |
| Development of an HPLC-UV method for the determination of scopoletin and umckalin in Pelargonium sidoides extracts and its commercial products | Marta Piestrzynska | 2006 |
| Detection of taxadiene sythase gene in Taxomyces andreanae by means of PCR | Magdalena Czepnik | 2006 |
| Genetic based screening for imvproved natural product discovery in Arabidopsis thaliana | Agata Staniak | 2004 |
| Isolation, structure elucidation and determination of immunomodulatory activity of Pelargonium sidoides extract Eps 7630 and its constituents | Weronika Trun | 2004 |
Bachelor Theses
| Titel | Name | Date |
| Optimization of the heterologous production of cannabinoids in Saccharomyces cerevisiae | Jennifer Katharina Jakob | January 2023 |
| Functional analysis of plant prenyltransferases in Saccharomyces cerevisiae | Makram Fataeri | August 2022 |
Die Entwicklung eines fluoreszenbasierten Screeningsystems zum Nachweis heterolog produzierter Cannabinoidsynthasen in Saccharomyces cerevisiae | Leon Frühauf | October 2021 |
| Untersuchung der Struktur-Funktionsbeziehungen der THCA-Synthase mit Fokus auf pH-abhängige Aktivität | Melissa Konomi | September 2021 |
| Evaluierung der Effizienz ausgewählter IRES-Sequenzen in Saccharomyces cerevisiae | Mara Loddenkemper | May 2021 |
| Heterologe Expression einer UDP-Glykosyltransferase aus Cantharanthus roseus in Komagataella phaffii | Robin Zimmer | April 2021 |
| Quantifizierung von Geranylpyrophosphat in Mevalonatweg-optimierten Stämmen von Saccharomyces cerevisiae | Frederike Heinen | January 2021 |
| Untersuchung von verschiedenen Carbonsäuren als alternative Substrate der Cannabinoidbiosynthese in Saccharomyces cerevisiae | Sarah Hallek | December 2020 |
| Struktur-Funktionsbeziehungen der Cannabichromensäuresynthase aus Cannabis sativa | Jan Baumeister | October 2020 |
| Konstruktion eines Fusionsproteins für die Entwicklung eines Screeningsystems zur Optimierung der thcas Expression in Saccharomyces cerevisiae | Lina Schibajew | October 2020 |
| Genomische Integration der Gene ARO4K229L, ARO7G141S, und AroL in Saccharomyces cerevisiae zur Optimierung des Shikimatwegs | Jonas Korb | February 2020 |
| Charakterisierung der Deletion DeltaYPL062W in Saccharomyces cerevisiae | Joel Hünewinckell | December 2019 |
| Untersuchungen zur Vermeidung von Hyperhydrizität in in vitro Zellkulturen von Cannabis sativa L. | Alina Faye Weltersbach | November 2019 |
| Untersuchungen zur Anwendbarkeit des Virus-induzierten Gen-Silencing-Systems in Cannabis sativa L. unter Verwendung des cabbage leaf curl virus | Leon Justen | October 2019 |
| Erstellung eines rekombinanten Saccharomyces cerevisiae-Stammes zur Steigerung der Geranyldiphosphatsyntheserate | Leonard Engels | April 2019 |
| Etablierung eines Mediendurchsatzscreeningsystems zur Untersuchung von NphB-Varianten | Sara Gröls | April 2019 |
| Ausarbeitung eines Transformationsprotokolls für Cannabis sativa L. mittels Agrobacterium tumefaciens | Ann-Katrin Rekendt | September 2018 |
| CRISPR/CAS9-basierter Knockout des Membrantransporters AQR1 zur Steigerung des intrazellulären Hexansäuregehaltes in Saccharomyces cerevisiae | Niklas Grimm | September 2018 |
| CRISPR/CAS9 basierte Integration von HAC1s in das Genom von Saccharomyces cerevisiae | Thomas Robitzky | July 2018 |
| Einfluss der Wachstumsbedingungen auf die Hexansäurebiosynthese in Saccharomyces cerevisiae | Katharina Tholen | June 2018 |
| CRISPR/CAS9-basierte Integration der Olivetolsynthase aus Cannabis sativa L. in Saccharomyces cerevisiae | Stefan Panzlaff | April 2018 |
| Identifikation häufiger Luftkeime | Dominik R. Bleidorn | April 2018 |
| Klonierung des Hac1-Gens zur Steigerung der THCAS-Expression in S. cerevisiae | David Bieniek | March 2018 |
| Expressionsstudien von NphB unter Verwendung verschiedener Vektorsysteme | Sarah Dybowski | August 2017 |
| Einfluss verschiedener Signalpeptide auf die intrazelluläre Lokalisierung der THCA-Synthse in Saccharomyces cerevisiae | Tim Orthwein | August 2017 |
| Klonierung und Charakterisierung des Cannabinoidstoffwechsels in E. coli zur heterologen Produktion von Canabigerolsäure | Christoph Alexander Schrage | June 2017 |
| Optimierung der Stem-loop PCR zur Detektion Cannabis sativa spezifischer micro RNAs | Katharina Kaufmann | May 2017 |
| Optimierung der heterologen Expression von Enterokinase in Escherichia coli | Philip Konwicka | May 2017 |
| Strategien zur gezielten Isolierung und Anreicherung von Cannabinoiden aus Cannabis sativa | Lisa Milena Bischoff | November 2016 |
| Der Einfluss von Phytohormonen und miRNAs auf die Trichomentwicklung in Cannabis sativa | Laura-Marie Zimmermann | September 2016 |
| Synthese und Charakterisierung von Geranyldiphosphat (GPP) für die Cannabinoidbiosynthese | Julia Grühn | October 2015 |
| Extraktion und Reinigung von Cannabinoiden aus Varietäten von Cannabis sativa | Matusah Gnaneswaran | October 2015 |
| Untersuchung von Limitierungsfaktoren der Delta9-Tetrahydrocannabinolsäure-Synthase-Expression in Saccharomyces cerevisiae | Martin Obholzer | September 2015 |
| Heterologe Expression und Aufreinigung von Delta9-Tetrahydrocannabinolsäure-Synthase | Anna Heitkamp | September 2015 |
| Anreicherung von Delta9-Tetrahydrocannabinolsäure-Synthase (THCA-Synthase) aus Cannabis sativa | Christoph Stoll | July 2015 |
| Erstellung und Charakterisierung von NphB-Varianten hinsichtlich der Substratspezifität | Ramona Hansmeyer | March 2015 |
| Optimierung der Proteinaufreinigung der Delta9-Tetrahydrocannabinolsäure-Synthase mittels Affinitätschromatographie | Anna Engelke | September 2014 |
| Heterologe Expression der Delta9-Tetrahydrocannabinolsäure-Synthase in Escherichia coli | Madeleine Dorsch | September 2014 |
| Heterologe Expression der Delta9-Tetrahydrocannabinolsäure-Synthase in Stämmen von Saccharomyces cerevisiae | Jana Rogoschin | September 2014 |
| Heterologe Expression der Delta9-Tetrahydrocannabinolsäure-Synthase in Saccharomyces cerevisiae | David Dannheisig | April 2014 |
| Extraktion, Isolierung und Identifikation von Cannabinoiden aus Cannabis sativa L. | Helene Sertznig | April 2014 |
| Heterologe Expression der Delta9-Tetrahydrocannabinolsäure-Synthase in Saccharomyces cerevisiae | Dirk Münker | December 2013 |
| Heterologe Expression von Tetrahydrocannabinolsäure-Synthase in Pichia pastoris | Sebastian Kollenda | October 2013 |
| Isolierung von Tetrahydrocannabinolsäure-Sythase aus Saccharomyces cerevisae YPL154C | Katharina Becker | February 2013 |
| Die Cannabigerolsäure-Synthase (CBGAS) aus Cannabis sativa L. -Untersuchungen zur heterologen Expression in Saccharomyces cerevisiae | Susan Henning | February 2013 |
| Cryopreservation, chemical and biochemical stability in hairy root cultures of Cannabis sativa var. bedrobinol | Johanna Petranowitsch | September 2012 |
| Herstellung von Tetrahydrocannabinol-Metaboliten mit humanem, rekombinanten P450 - Untersuchung analytischer, enzymkinetischer und verfahrenstechnischer Voraussetzungen | Michael Felten | March 2011 |
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Location & approach
The campus of the Technical University of Dortmund is located near the Dortmund West interchange, where the A45 Sauerland line crosses the B1/A40 Ruhr expressway. The Dortmund-Dorstfeld exit on the A40 leads to Campus-Nord. The university is signposted at both exits.
The "Dortmund Universität" S-Bahn station is located directly on the North Campus. From here, the S-Bahn line S1 runs every 15 or 30 minutes to Dortmund main station and in the opposite direction to Düsseldorf main station via Bochum, Essen and Duisburg. In addition, the university can be reached by bus lines 445, 447 and 462. Timetable information can be found on the homepage of the Rhine-Ruhr Transport Association. DSW21 also offer an interactive route network map.
One of the landmarks of the TU Dortmund is the H-Bahn. Line 1 runs every 10 minutes between Dortmund Eichlinghofen and the Technology Center via Campus South and Dortmund University S, while Line 2 commutes every 5 minutes between Campus North and Campus South. It covers this distance in two minutes.
From Dortmund Airport, the AirportExpress takes just over 20 minutes to Dortmund's main train station, and from there, the S-Bahn takes you to the university. A wider range of international flight connections is offered by Düsseldorf Airport, about 60 kilometers away, which can be reached directly by S-Bahn from the university's train station.
Interactive map
The facilities of TU Dortmund University are spread over two campuses, the larger Campus North and the smaller Campus South. Additionally, some areas of the university are located in the adjacent "Technologiepark".
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