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MSc Oliver Schiwy

Mail: Oliver Schiwy

Chair Technical Biochemistry

Emil-Figge-Str. 66, Room G1-6.25

44227 Dortmund

Phone: +49 231 755 7391

Oliver Schiwy © TU Dortmund

Field or research

Natural Products especially the class of secondary metabolites displays a remarkable array of biological activity and many of them are clinically valuable, among others, anti-microbial, anti-fungal and anti-tumor agents. These compounds of interest are often biosynthesized via nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs), which are multi-enzymatic, multi-domain megasynthases involved in the biosynthesis of nonribosomal peptides and polyketides. Providing the building blocks for these compounds to get sufficient yields is the main obstacle this project wants to tackle. Using Saccharomyces cerevisiae as a well characterized organism as a basis for the generation of a platform organism to provide elevated levels of precursor molecules for PKSs and NRPSs. To generate this PKS/NRPS ready organism genome editing methods like CRISPR/CAS9 are used.

Location & approach

The campus of the Technical University of Dortmund is located near the Dortmund West interchange, where the A45 Sauerland line crosses the B1/A40 Ruhr expressway. The Dortmund-Dorstfeld exit on the A40 leads to Campus-Nord. The university is signposted at both exits.

The "Dortmund Universität" S-Bahn station is located directly on the North Campus. From here, the S-Bahn line S1 runs every 15 or 30 minutes to Dortmund main station and in the opposite direction to Düsseldorf main station via Bochum, Essen and Duisburg. In addition, the university can be reached by bus lines 445, 447 and 462. Timetable information can be found on the homepage of the Rhine-Ruhr Transport Association. DSW21 also offer an interactive route network map.

 

One of the landmarks of the TU Dortmund is the H-Bahn. Line 1 runs every 10 minutes between Dortmund Eichlinghofen and the Technology Center via Campus South and Dortmund University S, while Line 2 commutes every 5 minutes between Campus North and Campus South. It covers this distance in two minutes.

From Dortmund Airport, the AirportExpress takes just over 20 minutes to Dortmund's main train station, and from there, the S-Bahn takes you to the university. A wider range of international flight connections is offered by Düsseldorf Airport, about 60 kilometers away, which can be reached directly by S-Bahn from the university's train station.

Interactive map

The facilities of TU Dortmund University are spread over two campuses, the larger Campus North and the smaller Campus South. Additionally, some areas of the university are located in the adjacent "Technologiepark".

Campus Lageplan Zum Lageplan